Parkinson’s Disease is a form of progressive neurodegeneration that primarily affects dopaminergic neurons, characterized by misfolded α-Syn proteins clumped together in Lewy Bodies. More recently, it has been proposed that α-Syn toxicity may increase during interactions with fatty acids. There have been a number of studies linking stearoyl-coenzyme A desaturase 1 (SCD1), the rate-limiting enzyme for the conversion of saturated fatty acids to monounsaturated fatty acids (MUFAs), to the increased toxicity of α-Syn. Conversely, SCD1 inhibition is shown to decrease the toxicity and aggregation of α-Syn. This project aims to synthesize seven novel analogs of SCD1 inhibitors, which are hypothesized to compete with saturated fatty acids to decrease their conversion into their respective MUFAs. Experimental results are coupled with in silico experiments using Autodock Vina to rationalize observed structure-activity relationships.